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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-124
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RPE cells; RB cell lines Y79, WERI-RB1, SO-Rb50 and HXO-RB45
Methods transfection, luciferase reporter assay, Western blot, qRT-PCR, autophagy assay
Expression pattern down-regulated
Functional description miR-124 regulates autophagy flux and could act as potent inhibitor of starvation-induced autophagy in Y79 cells. STX17 was involved in miR-124 regulation of retinoblastoma cell autophagy through miR-124 direct binding to the 3’UTR of STX17.
PubMed ID 29073720
Year 2018
Title MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation.
Drug-related ncRNA NO

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